100% Single-Use TFF Skid Eliminates Cross Contamination and Increases Market Reach
Novasep has launched the Sius single-use tangential flow filtration (TFF) skid. The TFF skid completes the Novasep proprietary, single-use TFF solution for pre-clinical to clinical cGMP biomanufacturing. The new skid is reportedly the first on the market to offer a 100% single-use TFF solution.
The Sius TFF skid is comprised of an automated benchtop unit with a fully disposable flowpath and is extremely compact. It is capable of laboratory to pilot scale TFF operations. Eliminating the risk of cross contamination, the unit widens the market for disposable TFF solutions, accommodating surface areas from 0.1 m2 to 2 m2 for microfiltration and ultrafiltration/diafiltration (UF/DF) applications.
Novasep has achieved a 73–80% reduction in consumable price to USD 800/m2 by designing the TangenX(R) Sius Single-use TFF cassettes to be more cost effective. This compares with $3,000/m2 to $4,000/m2 for competing products. The long-term drive by the biopharmaceutical industry to reduce costs, including the costly effort of cleaning equipment and validation, makes it increasingly reliant on disposable technologies. These offer numerous benefits over traditional reusable technologies. One of the most important of these is a time saving of 50–70% using Sius technology over traditional reusable TFF technologies.
The Novasep Sius TFF skid’s flowpath can be combined with TangenX Sius TFF cassettes and filter plate inserts with the option of a feed bag to provide a complete, single-use TFF solution from a single supplier for pre-clinical to clinical cGMP biomanufacturing. It is also one of the only solutions to enable cGMP validated integrity tests.
“As the biopharmaceutical market continues to evolve, demand continues to rise for more cost-effective and comprehensive solutions,” said Alain Lamproye, President of Novasep’s Biopharma business unit. “Novasep has reacted to this by concentrating on continuing to increase its product and service portfolio in the downstream processing marketplace and we will continue to do so. By launching Sius TFF Skid, Novasep now offers the first 100% single-use TFF solution on the market whilst remaining very cost effective. We are also developing a larger scale Sius TFF skid to cover commercial scale applications.”
Novasep, www.novasep.com.