'CO2 Control for Optimal Growth and Higher Yield in Fermentation' Webinar

Mettler-Toledo Process Analytics has released a new webinar intended for pharmaceutical producers involved in biofermentation. The webinar explains how optimal microorganism growth conditions and consequently higher process yield can be achieved through a programme of dissolved carbon dioxide measurement and control.

In biopharmaceutical operations, it is important that process reliability is high at all times. Central to this aim is timely measurement of analytical parameters. Well known key process parameters include pH, dissolved oxygen and turbidity. Less recognised but of significant importance in fermentation reactors is carbon dioxide.

Dissolved carbon dioxide levels can be indicative of the quality of cellular metabolism. High levels of CO₂ generally equate to high cellular growth; however, if CO₂ levels are excessive, they can reach a concentration that is toxic to the microorganisms. Low CO₂ levels lead to a slow growth rate and extended process duration. In-line CO₂ measurement systems provide continuous, real-time data on CO₂ concentration levels, allowing rapid corrective action when required.

Mettler-Toledo’s on-demand webinar illustrates how dissolved CO₂ measurement and control can keep fermentation cultures in their optimal growth range. This consequently increases process yield and efficiency of the fermentation process. The webinar also introduces Mettler-Toledo's InPro 5000i dissolved CO₂ sensor, which has been designed specifically for the requirements of the pharmaceutical industry. The webinar is available at www.mt.com.