Confused about cascade impaction? Watch and learn

Copley Scientific has released two new educational animations to explain critical aspects of inhaled product testing

The videos ‘How does a cascade impactor work?’ and ‘System for improved in vitro-in vivo correlations (IVIVCs) of inhaled drug products’ are designed to be a resource for training and for researchers new to inhaled product testing and/or those seeking enhanced testing strategies.

The size of particles delivered by an inhaled product influences where the drug deposits in the lung, affecting efficacy and is therefore considered a critical quality attribute. Uniquely, cascade impaction enables the generation of an aerodynamic particle size distribution specifically for the active pharmaceutical ingredient (API) within a formulation and is specified in the pharmacopoeias for the testing of all inhaled products.

‘How does a cascade impactor work?’ takes the viewer inside an animated cascade impactor to provide a step-by-step explanation of how it separates and collects particles for subsequent chemical analysis (typically by HPLC). The animation helps the understanding of this analytical technique, which can, at times, be a little difficult to understand.

The second animation presents an optimal test set-up that delivers enhanced IVIVCs, relative to standard pharmacopoeial test methods and explains how each key element works.

View them at www.vimeo.com/178587849 and www.vimeo.com/178588373.