Variable Gap Dry Granulator Meets Continuous Processing Requirements

The pharmaceutical industry’s demand for continuous processes is increasing because they offers clear advantages such as cost savings, process robustness and no scale-up hurdles. Continuous dry granulation is now often the process of choice for large-volume or moisture-sensitive products. L.B. Bohle meets this growing demand by offering the new Bohle BRC 100, a variable gap dry granulator.

The BRC 100 offers high-production capacity with minimal loss of material. This is achieved by fast and precise control of the compaction force with a new electromechanical spindle drive for the two rollers. In combination with a sensitive control of the variable gap via the screw feeding system, constant ribbon properties are assured over a wide production range from <1 kg to 200 kg per hour.

Sophisticated equipment design facilitates easy handling and shortens mounting procedures during working shifts. A hygienic design and properly integrated cleaning nozzles allow for an effective WIP process.

The BRC 100 achieves ribbon granulation with the Bohle Turbo Sieve (BTS 200). The conical sieve design allows gentle particle size reduction at low sieve speeds, which is also applicable at high material throughputs. A variety of different sieve types make it flexible for different product and ribbon properties.

The BRC 100 meets QbD requirements with its functional GMP design as well as with its ability to implement different PAT tools.

L.B. Bohle Maschinen + Verfahren GmbH, +49 2524 9323 150, t.borgers@lbbohle.de, www.lbbohle.de.