Silica-Based Excipient Delivers Enhanced Drug Solubility and Bioavailability

Merck Millipore, the Life Science division of Merck, has introduced Parteck SLC, a new excipient with a surface structure that delivers significantly increased loadability for APIs. Featuring a reportedly unique pore structure, Parteck SLC for drug delivery enables loading of oral dosage forms with amorphously distributed API to the highest levels, dramatically increasing API solubility.

“Many promising drug candidates fail during development due to poor bioavailability and represent a significant loss of time and resources invested in drug development,” noted Matthias Bucerius, Ph.D., Head of Pharmaceutical Raw Materials. “With the addition of Parteck SLC to our extensive portfolio of excipients, drug developers now have a new option to help increase solubility and bioavailability and advance drug development. With Parteck SLC, molecules can also be reformulated, potentially extending the lifecycle of the drug.”

Parteck SLC’s mesopores (2–7 µm) create a surface area of up to 1000 m²/g for depositing an API in its amorphous form needed for supersaturation. The internal surface area of Parteck SLC is also easily accessible and the API is always kept stable. Feasibility studies have proven the superior performance on dissolution of Parteck SLC both in vitro and in vivo.

A user-friendly particle size (5–25 μm) and bulk density (0.32 g/ml) allow easy loading, tabletting or capsule creation. In conjunction with Parteck ODT, a directly compressible excipient, Parteck SLC helps to produce stable and fast acting tablets. The loaded granulate retains its performance during dissolution in solid dosage forms.

As an EMPROVE product, Parteck SLC comes with ready-to-use documentation in CTD-format, saving time and money in the registration of the final drug. Feasibility studies concerning loading and in vitro dissolution are also available.

For more information, visit www.merckmillipore.com/bioavailability and www.merckmillipore.com/parteckslc.

Merck Millipore, +1 781 533 5336, pegeen.dossantos@emdmillipore.com, www.merckmillipore.com.