Polymer drug could prevent obesity

A group of scientists are developing a new class of compounds called “micelle sequestrant polymers,” or MSPs, that could prevent fat particles from getting absorbed in the body.

They report on their novel agents, which they tested on mice, in the ACS journal Biomacromolecules.

Targeting the body’s process of absorbing fat, the researchers designed a class of polymers that capture fat particles called micelles in the intestines so they can’t be digested. Instead, they pass through the gut and are excreted.

In tests, mice who took these MSPs had nine to 10 times the amount of triglycerides — the main dietary fat — in their feces than the control animals. Additionally, because the MSPs pass through the body unabsorbed, the researchers say they could provide a safe approach for long-term treatment.

The authors acknowledge funding from the University of Kansas Institute for Advancing Medical Innovation and the American Heart Association.