Aptamer Group, a developer of next-generation synthetic binders, has announced the adaptation of the Optimer-based test for Alzheimer’s disease into an Enzyme-Linked Immunosorbent Assay (ELISA).
Aptamer Group
This advance in test development follows the recent demonstration of an Optimer-based biosensor test that showed a statistically significant difference in levels of a novel Alzheimer’s disease biomarker between saliva samples from Alzheimer’s patients and healthy patient controls. Initial in-house validation of the plate-based ELISA assay at Aptamer has shown accurate detection of the biomarker over a clinically relevant range and compatibility with saliva for convenient patient sampling. The diagnostic test uses Aptamer Group’s Optimer binders, as synthetic antibody alternatives to detect a novel Alzheimer’s disease biomarker. The Neuro-Bio team, led by the eminent neuroscientist Baroness Susan Greenfield, discovered and validated the novel biomarker, an early disease biomarker with the potential to detect the disease before symptoms arise.
Further development efforts are being made to clinically validate the new test format. In parallel, Neuro-Bio is developing a treatment targeting the novel biomarker, which may be able to prevent Alzheimer’s disease symptoms from ever arising.
Aptamer has also finalised a royalty agreement with Neuro-Bio. Under the agreed terms, Aptamer is eligible to receive royalty payments with a blended royalty rate of 11.1% on the first £166 million of sales, with 5% thereafter for a 15-year term starting at first commercial sales across this diagnostic format. The partners estimate developing and validating a prototype ELISA assay for transfer to a manufacturer or distributor over the next 12-18 months.
The Alzheimer’s disease diagnostic market is valued at $8.3 billion, limited by the availability of any definitive diagnostic tests, and is expected to rise to $19.6 billion by 2029. While several Alzheimer’s diagnostics are in development, the test being developed by Aptamer and Neuro-Bio leverages non-invasive saliva sampling, offering a rapid, convenient and patient-friendly approach with the potential to transform the diagnostic market for this disease by increasing accessibility and accelerating time-to-diagnosis.
Dr. Arron Tolley, chief executive officer of Aptamer Group, said: “I am delighted that we have secured commercial terms with Neuro-Bio. This agreement underscores Apatmer’s model to establish ongoing revenue-generating opportunities in high-growth markets from the Group’s developed Optimer binders across its asset portfolio.
"Adapting the Optimer-based Alzheimer’s diagnostic into a widely compatible test format is a significant step forward in the Group’s mission to bring this test to market. The ability to integrate the test into existing hospital systems makes it easier for hospitals to adopt, providing a faster and easier route to market.
"The new strategic partnership with Neuro-Bio builds on the unique technical expertise of both companies to advance this innovative diagnostic solution toward commercialisation.”