Christina Victoria Craft
Advanced Measurement Equipment in Pharma Manufacturing.
Precise measurements have always been necessary for safe pharmaceutical manufacturing, even from the industry’s earliest stages. Many people only experience the desired therapeutic effects after following dose-dependent regimens. Although their physicians or pharmacists provide the specifics, manufacturers and their research teams initially determine and publish the details for how to get the best results without compromising safety.
Since incorrect measurements could cause safety risks and threaten efficacy, manufacturers must prioritise accuracy. How do advanced equipment and processes help them maintain quality control and public trust?
Testing Lab-Specific Workflows
Pharmaceutical manufacturers must consider numerous factors before bringing new measurement-related processes or equipment into their facilities. However, a specialised Virginia facility can remove much of the trial and error ordinarily associated with those efforts.
Its staff and equipment assist pharmaceutical industry clients with creating and quantifying new analytical processes. Process analytical technology is one area of expertise that focuses on helping companies monitor specific parameters impacting product quality.
Among the lab’s high-tech equipment is a benchtop nuclear magnetic resonance system that clients can use with a flow cell to monitor chemical reactions between pharmaceutical ingredients. Probe instruments allow them to take reaction-related measurements in the vessel and see how they change over time.
The associated data initially helps chemists design the desired reactions while maintaining the product’s purity and increasing yields. However, once manufacturing begins, workers take these measurements to verify that the identified responses proceed as expected and that the lab conditions are appropriate to facilitate them.
Once people verify the chemical reaction’s measurements, they may use automated tools that can periodically record the conditions and warn factory workers if something falls outside the set parameters. These time-saving measures are examples of the industry’s broader automation trend that allows employees to do more in less time. One company made and tested 1,000 mRNA sequences in a month this way, although manual methods allowed examining only 30.
Maintaining Consistency
The pharmaceutical industry must adhere to tight regulations to avoid scrutiny and prioritise safety. Advanced measuring equipment is essential for meeting those goals. Whether manufacturers are in the research and development phase or planning to ramp up production, advanced measurement equipment ensures they can succeed without sacrificing quality or bringing unwanted variables into their processes.
Manufacturers use scales to ensure medications — from injectables to painkiller tablets — remain the same from batch to batch. That commitment to quality control ensures that patients get the expected results from their medications. Although some pharmaceutical products cause different reactions in those who take them, well-calibrated measuring equipment removes that variability from the manufacturing environment.
A pharmaceutical scale’s readability increases based on the numbers shown after the decimal point. Selecting products with readability capabilities matching the drug created and the industry’s requirements allows manufacturers to achieve high output while removing potentially harmful variability.
Furthering Pharmaceutical Innovation
The pharmaceutical industry can save lives and put manufacturers at the forefront of progress. Advanced measuring devices are essential for those improvements. Some efforts help users make new conclusions they can apply to drug development and other ground-breaking work.
One team made a significant advancement in ion measurement that increases accuracy and tackles long-standing stability problems. Until this group’s discovery, the existing software and hardware to measure ions only allowed capturing data for one second and often generated unreliable results. However, strategic equipment alterations increased the measurement time to 25 seconds and gave much higher-resolution results than people could get from just one second.
Since this breakthrough allows pharmaceutical researchers to learn more about therapeutic proteins, it could have ripple effects in the manufacturing sector. It could enable the creation of more effective cancer treatments, vaccines, drug-delivery methods and more.
Keeping Pharmaceutical Companies Relevant
Pharmaceutical companies remain profitable by continually producing offerings to meet society’s health needs. Advanced measuring equipment allows them to stay competitive while emphasising their products’ safety and effectiveness to earn and retain customers’ trust.