Capsules
'Replacing HPLC for Content Uniformity Analysis by Transmission Raman — A Return on Investment Analysis' by Cobalt Light SystemsThis whitepaper compares resource requirements, operational time-savings and costs between HPLC and TRS methods. An analysis is performed based on replacing existing HPLC methods with faster TRS methods.
The cost of testing could be reduced significantly by replacing HPLC with a faster non-destructive method that requires fewer laboratory instruments. Alternative techniques include near-infrared spectroscopy, but this method can be cumbersome for creating and maintaining suitable and stable analytical models. However, CU analysis by Transmission Raman spectroscopy takes seconds per tablet, is less susceptible to the issues of model-building encountered in NIR and offers significant cost savings in regulated batch-testing.